A double-blind, placebo-controlled trial of memantine in age-associated memory impairment (memantine in AAMI).

Ferris S, Schneider L, Farmer M, Kay G, Crook T.

Alzheimer's Disease Center
 Silberstein Institute,
New York University School of Medicine
 New York, NY

Abstract

OBJECTIVES: To determine the safety and efficacy of memantine in treating Age-Associated Memory Impairment (AAMI).

METHODS: Sixty adults between 50-79 years of age meeting diagnostic requirements for AAMI were randomly assigned to either memantine (titrated to 20 mg) or a matched placebo and treated for 90 days. An extensive battery of computerized cognitive tests was administered at screening, baseline and, thereafter, at monthly intervals.

RESULTS AND CONCLUSION: Study results suggest that the primary cognitive effects of memantine in this population are on attention and information processing speed, rather than on memory. There were no differences in adverse events between memantine and placebo.
 

 | order |

Galantamine Alzheimer's articles      www.AlzheimersTreatments.com

Galantamine  fights Alzheimer's
   In the 1950s, a Bulgarian pharmacologist noticed that local villagers rubbed their foreheads with the snowdrop plant to ease nerve pain. Further investigation led to the isolation of the snowdrop extract galantamine  continue

Galantamine: why galantamine is the best agent for restoring memory
   Galantamine has several advantages over donepezil (Aricept®) and rivastigmine (Exelon®)    continue

Galantamine: can sharpen your mental edge
   Galantamine's positive results in slowing the progression of Alzheimer's disease may be due  continue

Galantamine: helps save Memory
   Galantamine is used in treating Alzheimer's disease, because of its ability   continue

Galantamine: beats Prescription Drugs for combating Mental Decline
  Galantamine is different from donepezil (Aricept®) and rivastigmine (Exelon®) in one very important way, galantamine has the unique ability to increase the receptiveness of nicotinic receptors to acetylcholine  continue

Galantamine: opens the channels of your Memory
   The secret of galantamine's success lies in your brain's nicotinic receptors.  continue

Galantamine:  Protect Brain Function by Enhancing Neurotransmission
   Galantamine has been found to be effective in treating  Alzheimer's disease   continue

Galantamine: Boost Memory
   Galantamine achieves the same effect as drugs such as Aricept or tacrine, but has additional benefits   continue

Galantamine protects Brain funtion
   The primary objective with Alzheimer's is to enhance neurotransmission so as to retain memory  continue
    
Galantamine: food for Mind & Body
   Galantamine is a flower extract that improves memory and perhaps even helps with impotence  continue

Galantamine  may help stave off Dementia
   Dementia is a progressive loss of memory accompanied by significant  continue

Galantamine: Memory Enhancement
   Alzheimer's patients  suffer sharp declines in their brain levels of acetylcholine. Galantamine    continue

Galantamine rescues Brain Cells
   According to a study of 653 Alzheimer's disease patients published in the British Medical Journal, the herbal supplement galantamine "appears to slow the progression of the neurodegenerative condition"  continue

Galantamine: the Old Become Young
   As we age, it becomes harder to learn new things. One explanation is the deterioration of the brain's continue

Galantamine: What's Old with Acetylcholine is New to Us
   Acetylcholine deficiency is characteristic of Alzheimer's disease. The primary treatment is administration of agents like galantamine, an extract from the snowdrop and daffodil plants  continue